Cam4 adult lk
Alterations in m RNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide Two acute monocytic leukemia (AML-M5a) cell lines (MOLM-13 and MOLM-14) with interclonal phenotypic heterogeneity showing MLL-AF9 fusion resulting from an occult chromosome insertion, ins(11;9)(q23;p22p23)This work was supported in part by Takeda Science Foundation (to CN) and JSPS KAKENHI Grant Number 14446690 (to CN).Author contributions Takayuki Ikezoe contributed to the concept and design, interpreted and analyzed the data and wrote the article.
Research, Evaluation & Special Studies module 3 (RESS3).
In addition, sh RNA-mediated downregulation of BCL2L12 increased the levels of cleaved caspase-3 and suppressed proliferation of leukemia cells, impairing their engraftment in immunodeficient mice.
Taken together, our results indicate that CD82 regulated BCL2L12 expression via STAT5A and AKT signaling and stimulated proliferation and engrafting of leukemia cells, suggesting that CD82 and BCL2L12 may be promising therapeutic targets in AML.
* Denotes the two studies (Perroud et al., 2014b and Martin-Blanco et al., 2014) that were included twice in this overview because they contained site-specific methylation data based on both adverse life experiences and adversity-related conditions. doi: 10.1017/S1461145713000102 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar Moore, L.
Heightened promoter methylation is typically associated with downregulation of gene expression, whereas intragenic methylation correlates with higher transcriptional activity (Jones, 2012; Moore et al., 2013; Yang et al., 2014).
Methodological issues have been raised with the aim of attempting to understand methylation quantification and site of action. doi: 10.1038/tp.2011.60 Pubmed Abstract | Pubmed Full Text | Cross Ref Full Text | Google Scholar Perroud, N., Rutembesa, E., Paoloni-Giacobino, A., Mutabaruka, J., Mutesa, L., Stenz, L., et al. The Tutsi genocide and transgenerational transmission of maternal stress: epigenetics and biology of the HPA axis.